Antidepressant and anxiolytic-like behavioral effects of erucamide, a bioactive fatty acid amide, involving the hypothalamus–pituitary–adrenal axis in mice
MM Li, Z Jiang, LY Song, ZS Quan, HL Yu - Neuroscience Letters, 2017 - Elsevier
Erucamide (Era) is a bioactive fatty acid amide, which is similar to the classical
endocannabinoid analogue oleoylethanolamide (OEA). In the present study, we
hypothesized that Era may regulate the central nervous system and may have the potential
to antagonize depression and anxiety. Therefore, we investigated the antidepressant and
anxiolytic effects of Era in animal models in comparison with fluoxetine (Fxt). Fifty mice were
randomly divided into 5 groups, and treated with a vehicle (0.3% methyl cellulose, 20 mL/kg …
endocannabinoid analogue oleoylethanolamide (OEA). In the present study, we
hypothesized that Era may regulate the central nervous system and may have the potential
to antagonize depression and anxiety. Therefore, we investigated the antidepressant and
anxiolytic effects of Era in animal models in comparison with fluoxetine (Fxt). Fifty mice were
randomly divided into 5 groups, and treated with a vehicle (0.3% methyl cellulose, 20 mL/kg …
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